INFLUENCE OF SINGLE NUCLEOTIDE VARIANTOF GENE LEP (rs3828942) ON ANTIPSYCHOTIC-INDUCED ABNORMAL GLUCOSE METABOLISMIN PATIENTS WITH SCHIZOPHRENIA
V.S. Dobrodeeva 1, M.Y. Tolmachev 1, N.A. Shnayder 1, Neznanov N.G. 1 , R.F. Nasyrova 1, 2, 3
1 V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, St. Petersburg, Russia
2 P.P. Kashchenko Psychiatric Hospital No 1, St. Petersburg, Russia
3 Kazan Federal University, Respublica Tatarstan, Kazan, Russia
Purpose: To study the influence of the polymorphic variant of the LEP gene Lys656Asn (rs3828942) on antipsychotic-induced changes in glucose concentration in patients residing in the European part of Russian Federation.
Materials and methods: A prospective study included 117 adult patients based on the presence of F2 disorders according to ICD-10 and the absence of serious somatic disorders residing in the European part of Russian Federation. Patients took antipsychotics in monotherapy.
Results: A allele of Lys656Asn polymorphism (rs3828942) of the LEP gene is associated with glucose concentration more than 6.1 mmol/L during antipsychotic therapy
Conclusions: Genetic polymorphisms of the leptin system (LEP Lys656Asn) could be a predictor of pre-diabetic state development during antipsychotic therapy.
Contact: nreginaf77@gmail.com
Citation:
V.S. Dobrodeeva, M.Y. Tolmachev, N.A. Shnayder, R.f. Nasyrova. Influence of single nucleotide variantof gene LEP (rs3828942) on antipsychotic-induced abnormal glucose metabolismin patients with schizophrenia // Sovrem. ter. psih. rasstrojstv. – 2020. – Vol. 1. – P. 16-20. DOI: 10.21265/PSYPH.2020.37.30.002
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